Enantioselective Claisen rearrangements: development of a first generation asymmetric acyl-Claisen reaction.
نویسندگان
چکیده
The development of an enantioselective catalytic Claisen rearrangement1 remains an important yet elusive goal in chemical synthesis.2 With this objective in mind, we recently reported the acyl-Claisen rearrangement, a Lewis acid-catalyzed variant of the Bellus reaction3 that utilizes acid chlorides and allylic amines in the stereoselective synthesis of R,â-disubstituted-γ,δ-unsaturated carbonyls (eq 1).4 In this communication, we demonstrate that
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ورودعنوان ژورنال:
- Journal of the American Chemical Society
دوره 123 12 شماره
صفحات -
تاریخ انتشار 2001